AvenCell is developing allogeneic, switchable CAR-T cell products that are engineered to overcome the limitations of current gene-edited allogeneic T cell therapies.
Autologous T cell therapies require manufacturing of individualized cell products, which has a high logistical and financial burden and also requires several weeks to manufacture. In contrast, allogeneic T cell therapies manufactured from healthy donors overcome these bottlenecks:
However, several immunological challenges must be overcome to provide a safe and persistent cell product with durable efficacy:
In conclusion, both host T cell and NK cell mediated immune rejection can lead to limited persistence of donor T cells and thus have a negative impact on their therapeutic efficacy. Avoidance of rejection by drug-induced host immune suppression is only temporary and promotes the risk of infections.
AvenCell is leveraging Intellia Therapeutics Inc.’s proprietary allogeneic platform based on CRISPR/Cas9 technology to overcome these challenges. AvenCell has been granted a license to combine Intellia’s CRISPR/Cas9 allogeneic platform with AvenCell’s universal, switchable CAR T-cell platforms. The in-licensed approach applies a novel combination of edits to generate allogeneic T cell products with durable persistence in hosts leading to superior anti-tumor efficacy.
This unique combination enables AvenCell to achieve long-term durability and persistence of its engineered T cells allowing for greater therapeutic efficacy.
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Chief Executive Officer
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