Science

AvenCell has developed proprietary next generation immunotherapy platforms that promise significant advantages over existing immunotherapies. We achieve this by making the most powerful therapies switchable, adaptable, persistent and readily available.

Universal Switchable CAR

Our Universal Switchable CAR platform combines the best of two worlds – the powerful anti-tumor response of CAR-T in combination with flexible soluble adaptors termed targeting modules (TM). This adds a clinically validated and unprecedented safety profile to our CAR-T, prevents their exhaustion and allows for a flexible targeting of multiple antigens in hematologic malignancies and solid tumors to overcome tumor escape and deepen responses.

TCE

AvenCell’s platform of T cell engaging bispecific antibody (TCE) is characterized by high binding affinity to tumor antigens and lower affinity to the CD3 antigen on effector T cells, preventing T cell auto-activation in pre-clinical models. The use of fully humanized antibodies reduces the risk of immunogenicity even in case of chronic dosing. Our lead clinical-stage TCE asset AVC-001 is globally partnered with Bristol-Myers Squibb. AVC-001 is a TCE with binding specificities to CD3 and PSCA, currently in early clinical development in multiple PSCA-positive advanced solid tumors.

Publications

Read more about the latest publications and presentations.

Andrew Schiermeier, Ph.D.

Chief Executive Officer

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